Our History

The core technology of the device is based on innovations developed by the head of Third Pole’s Scientific Advisory Board, Professor Warren Zapol at Harvard’s Massachusetts General Hospital. Professor Zapol was flying from Boston to Los Angeles to visit a colleague, who won the Nobel Prize for the discovery of NO’s biological role, when lightning inspired his pioneering idea to use electric current to produce NO. After meticulous follow-up work in his lab, and careful testing over several years, Professor Zapol and the Third Pole team developed an investigational device that uses proprietary technology to produce pure NO for inhalation on-demand from air, enabling bedside and portable therapeutic use.

Learn more about our founder:
In Memoriam – Warren M. Zapol, MD

Nitric Oxide– A Miracle Molecule Nitric Oxide

(NO) is a gas that is produced by the body and has the unique ability to relax blood vessels in the lungs without causing a dangerous drop in systemic blood pressure, which can be dangerous and is a significant disadvantage with other currently available therapies. Moreover, various scientific publications site that NO has anti-microbial properties that protect lungs against common bacteria, including both gram-positive and gram-negative, as well as against other diverse pathogens, including mycobacteria, viruses, fungi, yeast, and parasites, and has the potential to eliminate multi-drug resistant strains.

An animation of Nitric Oxide's effect on the lungs